Thrombotic microangiopathy can manifest in a diverse range of diseases and is characterized
by thrombocytopenia, microangiopathic hemolytic anemia, and organ injury, including AKI…

Background Pregnancy is associated with various forms of thrombotic microangiopathy,
including hemolytic uremic syndrome. A previous small French study suggested that pregnancy-…

Excessive type I interferon (IFNα/β) activity is implicated in a spectrum of human disease, yet
its direct role remains to be conclusively proven. We investigated two siblings with severe …

Factor H autoantibodies can impair complement regulation, resulting in atypical hemolytic
uremic syndrome, predominantly in childhood. There are no trials investigating treatment, and …

Thrombotic microangiopathy (TMA), characterized by organ injury occurring consequent to
severe endothelial damage, can manifest in a diverse range of diseases. In complement-…

The demonstration of impaired C regulation in the thrombotic microangiopathy (TMA)
atypical hemolytic uremic syndrome (aHUS) resulted in the successful introduction of the C …

… Author links open overlay panel Vicky Brocklebank 1 2 , Gurinder Kumar 3 , Alexander J.
Howie 4 , Jayanthi Chandar 5 , David V. Milford 4 , Janet Craze 6 , Jonathan Evans 7 , Eric …

The regulators of complement activation cluster at chromosome 1q32 contains the complement
factor H (CFH) and five complement factor H–related (CFHR) genes. This area of the …

EKG wrote the article and contributed to data collection and analysis. KSJ contributed to the
drafting of the article and data collection. VB contributed to the drafting of the article and data …

Membranoproliferative glomerulonephritis (MPGN), C3 glomerulopathy (C3G), atypical
haemolytic uraemic syndrome (aHUS) and age-related macular degeneration (AMD) have all …