Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting
enzyme 2 (ACE2) 1 , could represent a new chemoprophylactic approach for …

Background & Aims All oral direct acting antivirals (DAAs) effectively treat chronic hepatitis C
virus (HCV) infection, but the benefits in advanced liver disease are unclear. We compared …

Background & Aims Direct-acting antivirals have become widely used for patients with
chronic hepatitis C virus infection with decompensated cirrhosis. Virological responses are …

The study of biliary disease has been constrained by a lack of primary human cholangiocytes.
Here we present an efficient, serum-free protocol for directed differentiation of human …

The treatment of common bile duct (CBD) disorders, such as biliary atresia or ischemic
strictures, is restricted by the lack of biliary tissue from healthy donors suitable for surgical …

BACKGROUND/AIMS: Liver transplantation is an effective treatment for highly selected
patients with hepatocellular carcinoma (HCC), but tumour recurrence remains an important …

Organoid technology holds great promise for regenerative medicine but has not yet been
applied to humans. We address this challenge using cholangiocyte organoids in the context of …

Background. Late survival is not improving after liver transplantation. In this study, possible
reasons for this were investigated. Methods. Mortality rates and causes of death were …

We sought to identify factors that are predictive of liver transplantation or death in patients
with primary sclerosing cholangitis (PSC), and to develop and validate a contemporaneous …

… by two reviewers (Lukasz Krupa and William Gelson). We then independently collected
information … Phillips, and William Gelson) to determine if the studies should be included. We also …