Background Patients with acromegaly are treated with surgery, radiation therapy, and drugs
to reduce hypersecretion of growth hormone, but the treatments may be ineffective and have …

We used an exome-sequencing strategy and identified an allelic series of NOTCH2 mutations
in Hajdu-Cheney syndrome, an autosomal dominant multisystem disorder characterized …

Aldosterone-producing adenomas (APAs) are the commonest curable cause of hypertension.
Most have gain-of-function somatic mutations of ion channels or transporters. Herein we …

Context: In clinical practice, patients with acromegaly may be switched from therapy with
long-acting somatostatin analogs to pegvisomant. The effect of changing therapies on glucose …

Objective To investigate the early and late outcomes of patients with Cushing's disease (CD)
submitted to a neurosurgical procedure as first-line treatment. Design In this single-centre …

Background The effect of GH replacement on thyroid function in hypopituitary patients has
hitherto been studied in small groups of children and adults with conflicting results. Objective …

Context: Pituitary adenomas and pheochromocytomas/paragangliomas (pheo/PGL) can occur
in the same patient or in the same family. Coexistence of the two diseases could be due to …

Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma is a
common cause of hypertension. This can be cured, or greatly improved, by adrenal surgery. …

Until the advent of modern neuroradiological imaging techniques in 1989, a diagnosis of
GH deficiency in adults carried little significance other than as a marker of hypothalamo-…

Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of
ion channels or transporters. However, their frequency in aldosterone-producing cell clusters …