[PDF][PDF] Extrahepatic complications of nonalcoholic fatty liver disease

MJ Armstrong, LA Adams, A Canbay, WK Syn - Hepatology, 2014 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease, and is
strongly associated with the metabolic syndrome. In the last decade, it has become apparent …

Pathogenesis of alcohol‐induced liver disease: Classical concepts and recent advances

D Seth, PS Haber, WK Syn, AM Diehl… - Journal of …, 2011 - Wiley Online Library
Alcoholic liver disease (ALD) is a primary consequence of heavy and prolonged drinking.
ALD contributes to the bulk of liver disease burden worldwide. Progression of ALD is a …

[HTML][HTML] Hepatokines and adipokines in NASH-related hepatocellular carcinoma

O Kucukoglu, JP Sowa, GD Mazzolini, WK Syn… - Journal of …, 2021 - Elsevier
The incidence of hepatocellular carcinoma (HCC) is increasing in industrialized societies;
this is likely secondary to the increasing burden of non-alcoholic fatty liver disease (NAFLD) …

Non‐alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis

…, JF Schlaak, G Gerken, WK Syn… - … journal of cancer, 2011 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is the most common liver disease in developed
countries, and accumulating evidence suggests it as the hepatic manifestation of the metabolic …

[HTML][HTML] Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans

…, J Venter, HM Vandongen, WK Syn… - The Journal of …, 2008 - Am Soc Clin Investig
Epithelial-mesenchymal transitions (EMTs) play an important role in tissue construction during
embryogenesis, and evidence suggests that this process may also help to remodel some …

Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease

WK Syn, Y Htun Oo, TA Pereira, GF Karaca… - …, 2010 - Wiley Online Library
Liver inflammation is greater in nonalcoholic steatohepatitis (NASH) than steatosis, suggesting
that immune responses contribute to nonalcoholic fatty liver disease (NAFLD) progression…

[PDF][PDF] Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis

WK Syn, SS Choi, E Liaskou, GF Karaca… - …, 2011 - Wiley Online Library
Nonalcoholic steatohepatitis (NASH) is a leading cause of cirrhosis. Recently, we showed
that NASH‐related cirrhosis is associated with Hedgehog (Hh) pathway activation. The gene …

NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

WK Syn, KM Agboola, M Swiderska, GA Michelotti… - Gut, 2012 - gut.bmj.com
Objective Immune responses are important in dictating non-alcoholic steatohepatitis (NASH)
outcome. We previously reported that upregulation of hedgehog (Hh) and osteopontin (OPN…

Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease

WK Syn, Y Jung, A Omenetti, M Abdelmalek, CD Guy… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Repair responses define the ultimate outcomes of liver disease.
This study evaluated the hypothesis that fibrogenic repair in nonalcoholic fatty liver disease (…

[PDF][PDF] Pan‐caspase inhibitor VX‐166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

RP Witek, WC Stone, FG Karaca, WK Syn… - …, 2009 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a potentially progressive liver disease that culminates
in cirrhosis. Cirrhosis occurs more often in individuals with nonalcoholic steatohepatitis …