[PDF][PDF] Extrahepatic complications of nonalcoholic fatty liver disease
MJ Armstrong, LA Adams, A Canbay, WK Syn - Hepatology, 2014 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease, and is
strongly associated with the metabolic syndrome. In the last decade, it has become apparent …
strongly associated with the metabolic syndrome. In the last decade, it has become apparent …
Pathogenesis of alcohol‐induced liver disease: Classical concepts and recent advances
Alcoholic liver disease (ALD) is a primary consequence of heavy and prolonged drinking.
ALD contributes to the bulk of liver disease burden worldwide. Progression of ALD is a …
ALD contributes to the bulk of liver disease burden worldwide. Progression of ALD is a …
[HTML][HTML] Hepatokines and adipokines in NASH-related hepatocellular carcinoma
O Kucukoglu, JP Sowa, GD Mazzolini, WK Syn… - Journal of …, 2021 - Elsevier
The incidence of hepatocellular carcinoma (HCC) is increasing in industrialized societies;
this is likely secondary to the increasing burden of non-alcoholic fatty liver disease (NAFLD) …
this is likely secondary to the increasing burden of non-alcoholic fatty liver disease (NAFLD) …
Non‐alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis
…, JF Schlaak, G Gerken, WK Syn… - … journal of cancer, 2011 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is the most common liver disease in developed
countries, and accumulating evidence suggests it as the hepatic manifestation of the metabolic …
countries, and accumulating evidence suggests it as the hepatic manifestation of the metabolic …
[HTML][HTML] Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans
…, J Venter, HM Vandongen, WK Syn… - The Journal of …, 2008 - Am Soc Clin Investig
Epithelial-mesenchymal transitions (EMTs) play an important role in tissue construction during
embryogenesis, and evidence suggests that this process may also help to remodel some …
embryogenesis, and evidence suggests that this process may also help to remodel some …
Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease
WK Syn, Y Htun Oo, TA Pereira, GF Karaca… - …, 2010 - Wiley Online Library
Liver inflammation is greater in nonalcoholic steatohepatitis (NASH) than steatosis, suggesting
that immune responses contribute to nonalcoholic fatty liver disease (NAFLD) progression…
that immune responses contribute to nonalcoholic fatty liver disease (NAFLD) progression…
[PDF][PDF] Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis
WK Syn, SS Choi, E Liaskou, GF Karaca… - …, 2011 - Wiley Online Library
Nonalcoholic steatohepatitis (NASH) is a leading cause of cirrhosis. Recently, we showed
that NASH‐related cirrhosis is associated with Hedgehog (Hh) pathway activation. The gene …
that NASH‐related cirrhosis is associated with Hedgehog (Hh) pathway activation. The gene …
NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease
WK Syn, KM Agboola, M Swiderska, GA Michelotti… - Gut, 2012 - gut.bmj.com
Objective Immune responses are important in dictating non-alcoholic steatohepatitis (NASH)
outcome. We previously reported that upregulation of hedgehog (Hh) and osteopontin (OPN…
outcome. We previously reported that upregulation of hedgehog (Hh) and osteopontin (OPN…
Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease
WK Syn, Y Jung, A Omenetti, M Abdelmalek, CD Guy… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Repair responses define the ultimate outcomes of liver disease.
This study evaluated the hypothesis that fibrogenic repair in nonalcoholic fatty liver disease (…
This study evaluated the hypothesis that fibrogenic repair in nonalcoholic fatty liver disease (…
[PDF][PDF] Pan‐caspase inhibitor VX‐166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis
RP Witek, WC Stone, FG Karaca, WK Syn… - …, 2009 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a potentially progressive liver disease that culminates
in cirrhosis. Cirrhosis occurs more often in individuals with nonalcoholic steatohepatitis …
in cirrhosis. Cirrhosis occurs more often in individuals with nonalcoholic steatohepatitis …