A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
Y Sun, X Jiang, S Chen… - Proceedings of the …, 2005 - National Acad Sciences
The ataxia telangiectasia mutant (ATM) protein kinase regulates the cell's response to DNA
damage through the phosphorylation of proteins involved in cell-cycle checkpoints and DNA …
damage through the phosphorylation of proteins involved in cell-cycle checkpoints and DNA …
Ecotoxicity and genotoxicity of polystyrene microplastics on higher plant Vicia faba
X Jiang, H Chen, Y Liao, Z Ye, M Li, G Klobučar - Environmental Pollution, 2019 - Elsevier
Nano- and microplastics have been widely spread in environmental matrices, especially in
marine and terrestrial systems. In this study, higher plant Vicia faba root tips were exposed to …
marine and terrestrial systems. In this study, higher plant Vicia faba root tips were exposed to …
The activation of MAPK in melanoma cells resistant to BRAF inhibition promotes PD-L1 expression that is reversible by MEK and PI3K inhibition
X Jiang, J Zhou, A Giobbie-Hurder, J Wargo… - Clinical cancer …, 2013 - AACR
Purpose: Selective BRAF inhibition (BRAFi) provides a paradigm shift for melanoma treatment.
The duration of benefit is typically limited before resistance develops. Interest remains in …
The duration of benefit is typically limited before resistance develops. Interest remains in …
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
Y Sun, X Jiang, Y Xu, MK Ayrapetov, LA Moreau… - Nature cell …, 2009 - nature.com
DNA double-strand break (DSB) repair involves complex interactions between chromatin and
repair proteins, including Tip60, a tumour suppressor 1 . Tip60 is an acetyltransferase that …
repair proteins, including Tip60, a tumour suppressor 1 . Tip60 is an acetyltransferase that …
[HTML][HTML] Predicting treatment response from longitudinal images using multi-task deep learning
Radiographic imaging is routinely used to evaluate treatment response in solid tumors. Current
imaging response metrics do not reliably predict the underlying biological response. Here…
imaging response metrics do not reliably predict the underlying biological response. Here…
Toxicological effects of polystyrene microplastics on earthworm (Eisenia fetida)
X Jiang, Y Chang, T Zhang, Y Qiao, G Klobučar… - Environmental …, 2020 - Elsevier
Microplastics are plastic fragments of particle sizes less than 5 mm, which are widely
distributed in marine and terrestrial environments. In this study, earthworms Eisenia fetida were …
distributed in marine and terrestrial environments. In this study, earthworms Eisenia fetida were …
[HTML][HTML] Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation
Y Sun, X Jiang, S Chen, BD Price - FEBS letters, 2006 - Elsevier
Histone acetyltransferases (HATs) regulate transcription, chromatin structure and DNA repair.
Here, we utilized a novel HAT inhibitor, anacardic acid, to examine the role of HATs in the …
Here, we utilized a novel HAT inhibitor, anacardic acid, to examine the role of HATs in the …
Tip60: connecting chromatin to DNA damage signaling
Y Sun, X Jiang, BD Price - Cell cycle, 2010 - Taylor & Francis
Cells are constantly exposed to genotoxic events that can damage DNA. To counter this,
cells have evolved a series of highly conserved DNA repair pathways to maintain genomic …
cells have evolved a series of highly conserved DNA repair pathways to maintain genomic …
[HTML][HTML] The role of circulating microRNA-126 (miR-126): a novel biomarker for screening prediabetes and newly diagnosed type 2 diabetes mellitus
…, C Yang, K Zhou, B Shen, H Liang, X Jiang - International journal of …, 2014 - mdpi.com
Recent studies suggested an association of endothelial microRNA-126 (miR-126) with type
2 diabetes mellitus (T2DM). In the current study, we examined whether circulating miR-126 …
2 diabetes mellitus (T2DM). In the current study, we examined whether circulating miR-126 …
[HTML][HTML] Anti-GPC3-CAR T cells suppress the growth of tumor cells in patient-derived xenografts of hepatocellular carcinoma
Z Jiang, X Jiang, M Peng, P Li - Frontiers in immunology, 2017 - frontiersin.org
Background The lack of a general clinic-relevant model for human cancer is a major
impediment to the acceleration of novel therapeutic approaches for clinical use. We propose to …
impediment to the acceleration of novel therapeutic approaches for clinical use. We propose to …