Embryonic stem (ES) cells are unique in their ability to self-renew indefinitely and maintain
pluripotency. These properties require transcription factors that specify the gene expression …

Detection of new genomic control elements is critical in understanding transcriptional regulatory
networks in their entirety. We studied the genome-wide binding locations of three key …

The dominant effect of transcription factors in imparting expanded potency is best
exemplified by the reprogramming of fibroblasts to pluripotent cells using retrovirus-mediated …

The derivation of human ES cells (hESCs) from human blastocysts represents one of the
milestones in stem cell biology 1 . The full potential of hESCs in research and clinical …

Human embryonic stem cells (hESCs) are derived from the inner cell mass of the blastocyst.
Despite sharing the common property of pluripotency, hESCs are notably distinct from …

About half of the human genome consists of highly repetitive elements, most of which are
considered dispensable for human life. Here, we report that repetitive elements originating …

Identifying pairwise RNA-RNA interactions is key to understanding how RNAs fold and interact
with other RNAs inside the cell. We present a high-throughput approach, sequencing of …

Background & Aims There are few in vitro models for studying the 3-dimensional interactions
among different liver cell types during organogenesis or disease development. We aimed …

During differentiation, human embryonic stem cells (hESCs) shut down the regulatory network
conferring pluripotency in a process we designated pluripotent state dissolution (PSD). In …

The insulated gate bipolar transistor (IGBT) modules are getting more accepted and
increasingly used in power electronic systems as high power and high voltage switching …