[HTML][HTML] Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

GK Schwaerzer, H Kalyanaraman, DE Casteel… - Nature …, 2019 - nature.com
People heterozygous for an activating mutation in protein kinase G1 (PRKG1, p. Arg177Gln)
develop thoracic aortic aneurysms and dissections (TAAD) as young adults. Here we report …

Sudden headache due to perimesencephalic subarachnoid hemorrhage after self-medication with 200 mg sildenafil: Case report and discussion

TA Wagner-Altendorf, T Boppel, R Herzog… - Clinical Neurology and …, 2020 - Elsevier
3. Discussion The use of sildenafil, which is approved to treat erectile dysfunction as well as
pulmonary arterial hypertension, has been associated with bleeding incidents in several …

Treatment for aortic aneurysms

B Gerard, D Casteel, H Rangaswami… - US Patent App. 17 …, 2022 - Google Patents
Compositions and methods for treatment of aortic disease in a subject in need comprising
an effective amount of cobi namide. Aortic diseases include for example aortic aneu rysm …

Treatment for aortic aneurysms

B Gerard, D CASTEEL, H RANGASWAMI, P Renate - 2020 - Google Patents
FEESAGIUMZGLMF-JFYQDRLCSA-M Cobinamide Chemical compound [Co+3].[N-]([C@@
H] 1 [C@ H](CC (N)= O)[C@@] 2 (C) CCC (= O) NC [C@ H](O) C)\C2= C (C)/C ([C@ H](C\2 …