Among the different etiologies for fever of unknown origin in children, infectious diseases are
the most frequent final diagnosis, followed by autoimmune diseases and malignancies …

Our purpose in this study was to learn the subsequent course of a series of 173 patients
discharged from the Peter Bent Brigham Hospital with the diagnosis of fever of unknown …

Background Patients with persistent fevers of undetermined etiology often undergo
extensive evaluation without a diagnosis. Autoinflammatory syndromes may not always be …

Purpose Fever is one of the most common symptoms in children. In previous studies,
infectious disease was the most common cause of pediatric fever of unknown origin (FUO) …

Autoinflammatory disorders (AIDs) are a subgroup of immune-mediated syndromes that
result from a primary dysfunction of the innate immune system. AIDs can be either …

Background: Fever of unknown origin (FUO) is still a challenge for clinicians. Next-
generation sequencing technologies, such as whole exome sequencing (WES), can be …

This article revisits concepts of pyrexia of unknown origin to reflect current clinical practice. It
describes the evolution of the term, in line with the changing spectrum and pace of …

Abstract Background Tumor Necrosis Factor Receptor-Associated Periodic Syndrome
(TRAPS) is the second most common heritable autoinflammatory disease, typically …

Background Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA)
syndrome is generally regarded as the most common autoinflammatory disease, but the …

During the recent years the identification of monogenic mutations that cause sterile
inflammation has expanded the spectrum of autoinflammatory diseases, clinical disorders …