Systemic sclerosis, also called scleroderma, is an immune-mediated rheumatic disease that
is characterised by fibrosis of the skin and internal organs and vasculopathy. Although …

ABSTRACT Introduction: Systemic sclerosis (SSc) is a complex autoimmune connective
tissue disease characterized by chronic and progressive tissue and organ fibrosis with …

Vitamin D is a steroid hormone with potent immune-modulating properties. It has been
shown to stimulate innate immunity and induce immune tolerance. Extensive research …

Systemic sclerosis (SSc) is an intractable multifaceted disease with high mortality. Although
its pathogenesis is not fully understood, recent studies have advanced our knowledge on …

In early systemic sclerosis (Scleroderma, SSc), the vasculature is impaired. Although the
exact etiology of endothelial cell damage in SSc remains unclear, it is hypothesized that …

Background Gastrointestinal tract (GIT) involvement is a common cause of debilitating
symptoms in patients with systemic sclerosis (SSc). There are no disease modifying …

Registry data worldwide indicate an overall female predominance for pulmonary arterial
hypertension (PAH) of 2–4 over men. Genetic predisposition accounts for only 1–5% of PAH …

Oro-facial fibrosis in systemic sclerosis (Scleroderma; SSc) has a major impact on mouth
function, facial appearance, and patient quality of life. Lipotransfer is a method of …

Purpose This study aimed to investigate the association between vitamin D and systemic
sclerosis (SSc) by meta-analysis. Methods A comprehensive search was performed through …

Background: MicroRNAs are short nucleotide sequences that contribute to the regulation of
various biological functions and therefore their roles have been investigated in many …