Background Growth differentiation factor-15 (GDF-15) is a promising biomarker of cardiac
remodeling. The purpose of this study was to explore the diagnostic value of plasma GDF-15 …

emotionally. As is highlighted, our decision making must be underpinned by the mantra 'no
decision about me, without me', which is of utmost importance in this vulnerable population …

Although major therapeutic advances have been achieved in the last decade, clinical
experience shows that patients with chronic heart failure (HF) are exposed to a high risk of …

Following the results of the PARADIGM-HF trial, the European Society of Cardiology (ESC)
guidelines recommend sacubitril/valsartan to replace ACE inhibitors in ambulatory patients …

The optimal use of sacubitril/valsartan in clinical practice needs further investigation, in
particular for patients with multiple comorbidities, as such patients are usually poorly …

Sacubitril/valsartan (neprilysin inhibitor/angiotensin receptor blocker combination) was
compared to enalapril in stable patients who had heart failure with reduced ejection fraction …

Apesar dos grandes avanços terapêuticos, a insuficiência cardíaca (IC), disfunção sistólica
do ventrículo esquerdo e doenças hipertensivas, tem se tornado cada vez mais …

La insuficiencia cardiaca es un problema de salud en todo el mundo, con altos costos
sociales y económicos que no pueden ser afrontados solo por los pacientes o sus …