[HTML][HTML] Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial

N Sprigg, K Flaherty, JP Appleton, RAS Salman… - The Lancet, 2018 - thelancet.com
Background Tranexamic acid can prevent death due to bleeding after trauma and post-
partum haemorrhage. We aimed to assess whether tranexamic acid reduces haematoma …

[HTML][HTML] Luteolin Exerts Neuroprotection via Modulation of the p62/Keap1/Nrf2 Pathway in Intracerebral Hemorrhage

X Tan, Y Yang, J Xu, P Zhang, R Deng… - Frontiers in …, 2020 - frontiersin.org
Upregulation of neuronal oxidative stress is involved in the progression of secondary brain
injury (SBI) following intracerebral hemorrhage (ICH). In this study, we investigated the …

[PDF][PDF] Fibroblasts repair blood-brain barrier damage and hemorrhagic brain injury via TIMP2

L Xu, A Nirwane, T Xu, M Kang, K Devasani, Y Yao - Cell reports, 2022 - cell.com
The function of fibroblasts in intracerebral hemorrhage (ICH) remains elusive. By targeting
Col1α1, a fibroblast-specific marker, we generate mice with ablated Col1α1+ fibroblasts …

[HTML][HTML] Stroke unit care, inpatient rehabilitation and early supported discharge

H Rodgers, C Price - Clinical Medicine, 2017 - ncbi.nlm.nih.gov
Stroke units reduce death and disability through the provision of specialist multidisciplinary
care for diagnosis, emergency treatments, normalisation of homeostasis, prevention of …

Managing high blood pressure during acute ischemic stroke and intracerebral hemorrhage

KO Appiah, JS Minhas… - Current Opinion in …, 2018 - journals.lww.com
There are clear national and international guidelines on BP lowering for specific indications,
as well as ongoing clinical trials aiming to address common clinical scenarios in which the …

[HTML][HTML] Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT.

N Sprigg, K Flaherty, JP Appleton… - Health Technology …, 2019 - ncbi.nlm.nih.gov
OBJECTIVE The aim of the study was to assess if tranexamic acid is safe, reduces
haematoma expansion and improves outcomes in adults with spontaneous intracerebral …

[HTML][HTML] Injectable collagen scaffold with human umbilical cord-derived mesenchymal stem cells promotes functional recovery in patients with spontaneous …

XY Li, WS Deng, ZQ Wang, ZC Li… - Neural Regeneration …, 2023 - journals.lww.com
Animal experiments have shown that injectable collagen scaffold with human umbilical cord-
derived mesenchymal stem cells can promote recovery from spinal cord injury. To …

Acute spontaneous intracerebral haemorrhage: treatment and management

S Mc Lernon, PS Nash… - British Journal of …, 2022 - magonlinelibrary.com
Acute spontaneous intracerebral haemorrhage is a devastating form of stroke, with high
rates of mortality and disability in survivors. Despite the burden of intracerebral …

Critical care transport of patients with brain injuries

R Zayas - AACN advanced critical care, 2018 - AACN
Critical care transport began in the 1970s as a response to the growing need to be able to
transport critically ill and injured patients to tertiary care centers for higher levels of care or …

Interventional ultrasound assisted early local hemostatic drug therapy in traumatic intracerebral hemorrhage

C Feng, S Huang, X Zhou, L Wang, X Cui… - Ultrasound in Medicine …, 2020 - Elsevier
This article aims to test a minimally invasive interventional approach by real-time
transcranial contrast-enhanced ultrasound (CEUS) through a small bur hole to achieve an …