[HTML][HTML] mRNA-based therapeutics: powerful and versatile tools to combat diseases
S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
[HTML][HTML] Metabolic messengers: tumour necrosis factor
JK Sethi, GS Hotamisligil - Nature metabolism, 2021 - nature.com
Tumour necrosis factor (TNF) is a classical, pleiotropic pro-inflammatory cytokine. It is also
the first 'adipokine'described to be produced from adipose tissue, regulated in obesity and …
the first 'adipokine'described to be produced from adipose tissue, regulated in obesity and …
[HTML][HTML] Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …
Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis
YL Chen, D Gutowska-Owsiak, CS Hardman… - Science translational …, 2019 - science.org
Targeted inhibition of cytokine pathways provides opportunities to understand fundamental
biology in vivo in humans. The IL-33 pathway has been implicated in the pathogenesis of …
biology in vivo in humans. The IL-33 pathway has been implicated in the pathogenesis of …
Engineering polyphenol-based polymeric nanoparticles for drug delivery and bioimaging
Polyphenols are compounds with phenolic hydroxyl groups that are widely found in natural
plants. The beneficial effects of polyphenols have been studied extensively, especially anti …
plants. The beneficial effects of polyphenols have been studied extensively, especially anti …
[PDF][PDF] Pandemic preparedness: developing vaccines and therapeutic antibodies for COVID-19
GD Sempowski, KO Saunders, P Acharya, KJ Wiehe… - Cell, 2020 - cell.com
The SARS-CoV-2 pandemic that causes COVID-19 respiratory syndrome has caused global
public health and economic crises, necessitating rapid development of vaccines and …
public health and economic crises, necessitating rapid development of vaccines and …
[HTML][HTML] Microalgae with immunomodulatory activities
G Riccio, C Lauritano - Marine drugs, 2019 - mdpi.com
Microalgae are photosynthetic microorganisms adapted to live in very different environments
and showing an enormous biochemical and genetic diversity, thus representing an excellent …
and showing an enormous biochemical and genetic diversity, thus representing an excellent …
[HTML][HTML] Approaches towards fighting the COVID‑19 pandemic
Abstract The coronavirus disease 2019 (COVID‑19) outbreak, which has caused> 46
millions confirmed infections and> 1.2 million coronavirus related deaths, is one of the most …
millions confirmed infections and> 1.2 million coronavirus related deaths, is one of the most …
[HTML][HTML] Safety, immunogenicity and interchangeability of biosimilar monoclonal antibodies and fusion proteins: a regulatory perspective
P Kurki, S Barry, I Bourges, P Tsantili, E Wolff-Holz - Drugs, 2021 - Springer
Background Biosimilars have been used for 15 years in the European Union (EU), and have
been shown to reduce costs and increase access to important biological medicines. In spite …
been shown to reduce costs and increase access to important biological medicines. In spite …
[HTML][HTML] Mesoporous silica nanoparticles: Properties and strategies for enhancing clinical effect
AN Frickenstein, JM Hagood, CN Britten, BS Abbott… - Pharmaceutics, 2021 - mdpi.com
Due to the theragnostic potential of mesoporous silica nanoparticles (MSNs), these were
extensively investigated as a novel approach to improve clinical outcomes. Boasting an …
extensively investigated as a novel approach to improve clinical outcomes. Boasting an …