Current and emerging pharmacotherapeutic interventions for the treatment of liver fibrosis

J Lambrecht, LA van Grunsven… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Chronic liver disease is due to various causes of persistent liver damage and
will eventually lead to the development of liver fibrosis. If no treatment is initiated, this …

[HTML][HTML] Acute-on-chronic liver failure: pathophysiological mechanisms and management

A Khanam, S Kottilil - Frontiers in medicine, 2021 - frontiersin.org
Acute-on-chronic liver failure (ACLF) is a multifaceted condition with poor treatment options
and high short-term mortality. ACLF can develop in patients with or without liver cirrhosis …

[HTML][HTML] What do we know about inequalities in NAFLD distribution and outcomes? A scoping review

M Talens, N Tumas, JV Lazarus, J Benach… - Journal of clinical …, 2021 - mdpi.com
With prevalence high and rising given the close relationship with obesity and diabetes
mellitus, non-alcoholic fatty liver disease (NAFLD) is progressively becoming the most …

Liver cirrhosis and immune dysfunction

E Hasa, P Hartmann, B Schnabl - International immunology, 2022 - academic.oup.com
Cirrhosis is end-stage liver disease resulting from various etiologies and is a common cause
of death worldwide. The progression from compensated to decompensated cirrhosis to …

Pathophysiology and management of variceal bleeding

SA Alqahtani, S Jang - Drugs, 2021 - Springer
Cirrhosis is the fifth leading cause of death in adults. Advanced cirrhosis can cause
significant portal hypertension (PH), which is responsible for many of the complications …

The role of alcohol use in the aetiology and progression of liver disease: A narrative review and a quantification

J Rehm, J Patra, A Brennan, C Buckley… - Drug and alcohol …, 2021 - Wiley Online Library
Issues Alcohol use has been shown to impact on various forms of liver disease, not
restricted to alcoholic liver disease. Approach We developed a conceptual framework based …

[HTML][HTML] Alcohol use disorders and the risk of progression of liver disease in people with hepatitis C virus infection–a systematic review

L Llamosas-Falcón, KD Shield, M Gelovany… - … , prevention, and policy, 2020 - Springer
Liver cirrhosis and other chronic liver diseases are usually compartmentalized into separate
categories based on etiology (eg, due to alcohol, virus infection, etc.), but it is important to …

MRI Extracellular Volume Fraction in Liver Fibrosis—A Comparison of Different Time Points and Blood Pool Measurements

VC Obmann, M Ardoino, J Klaus… - Journal of Magnetic …, 2024 - Wiley Online Library
Background Extracellular volume (ECV) correlates with the degree of liver fibrosis. Purpose
To analyze the performance of liver MRI‐based ECV evaluations with different blood pool …

[HTML][HTML] Efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPS) created using covered stents of different diameters: A systematic review and meta …

Z Huang, Q Yao, J Zhu, Y He, Y Chen, F Wu… - Diagnostic and …, 2021 - Elsevier
Purpose The purpose of this study was to make a systematic review and meta-analysis to
determine the stent diameter (8 mm vs. 10 mm) that conveys better safety and clinical …

[HTML][HTML] Potential role of noninvasive biomarkers during liver fibrosis

N Kaur, G Goyal, R Garg, C Tapasvi… - World journal of …, 2021 - ncbi.nlm.nih.gov
Various types of liver disease exist, such as hepatitis and alcoholic liver disease. These liver
diseases can result in scarring of liver tissue, cirrhosis, and finally liver failure. During liver …