Cardiovascular disease and infections are major causes for the high incidence of morbidity
and mortality of patients with chronic kidney disease. Both complications are directly or …

The complement system comprises the frontline of the innate immune system. Triggered by
pathogenic surface patterns in different pathways, the cascade concludes with the formation …

The complement system, an arm of the innate immune system plays a critical role in both
health and disease. The complement system is highly complex with dual possibilities …

Introduction Dysregulated complement activation is likely the primary driver of disease in C3
glomerulopathy (C3G) and contributes to other complement-mediated diseases, including …

Arctium lappa L., also known as burdock, is an edible wild plant which has the ability to grow
in distinct environments and is considered a weed in several parts of the world. This species …

This study sought to characterize the impact of long-term dehydration in terms of
physiological and biochemical parameters, as well as renal transcriptomes. Furthermore, we …

Background: C3 glomerulopathy (C3G), a rare glomerular disease mediated by alternative
complement pathway dysregulation, is associated with a high rate of recurrence and graft …

Dysregulated activation of the complement system is implicated in the onset or progression
of several diseases. Most clinical-stage complement inhibitors target the inactive …

Chronic low-grade inflammation is a key contributor to the progression of kidney disease.
The release of cytokines and other pro-inflammatory proteins may further contribute to …

Background Children with immunoglobulin A vasculitis (IgAV Henoch-Schönlein purpura)
frequently encounter nephritis (IgAV-N) with 1–2% risk of kidney failure. The …