Low Percentage of Perforin-Expressing NK Cells during Severe SARS-CoV-2 Infection: Consumption Rather than Primary Deficiency

L Kundura, R Cezar, E Ballongue, S André… - The Journal of …, 2024 - journals.aai.org
Genetic defects in the ability to deliver effective perforin have been reported in patients with
hemophagocytic lymphohistiocytosis. We tested the hypothesis that a primary perforin …

[PDF][PDF] Hemophagocytic Syndrome and COVID-19: A Comprehensive Review

MM Fadlallah, SM Salman, MM Fadlallah, H Rahal… - Cureus, 2023 - cureus.com
Hemophagocytic lymphohistiocytosis (HLH), a hyperinflammatory hyperferritinemic
syndrome, is triggered by various etiologies and diseases and can lead to multiorgan …

[HTML][HTML] A hyperinflammation clinical risk tool, HI5-NEWS2, stratifies hospitalised COVID-19 patients to associate risk of death and effect of early dexamethasone in an …

MR Ardern-Jones, HTT Phan, F Borca, M Stammers… - PLoS …, 2023 - journals.plos.org
Background The success of early dexamethasone therapy for hospitalised COVID-19 cases
in treatment of Sars-CoV-2 infection may predominantly reflect its anti-inflammatory action …

A novel hyperinflammation clinical risk tool, HI5-NEWS2, predicts mortality following early dexamethasone use in an observational cohort of hospitalised COVID-19 …

MR Ardern-Jones, HTT Phan, F Borca, M Stammers… - medRxiv, 2021 - medrxiv.org
Background The success of early dexamethasone therapy for hospitalised COVID-19 cases
in treatment of Sars-CoV-2 infection may predominantly reflect its anti-inflammatory action …

[PDF][PDF] Evaluation of Outcome in Patients With Moderate and Severe COVID-19 Via H-Score

S Tehrani, H Shabanpour Dehbaneh… - International Journal of …, 2022 - academia.edu
Background: Due to uncontrolled lymphocyte reaction, the overproduction of cytokines in
COVID-19 patients can cause sepsis-like symptoms, suggesting sepsis, cytokine release …