[HTML][HTML] The next generation of evidence-based medicine
V Subbiah - Nature medicine, 2023 - nature.com
Recently, advances in wearable technologies, data science and machine learning have
begun to transform evidence-based medicine, offering a tantalizing glimpse into a future of …
begun to transform evidence-based medicine, offering a tantalizing glimpse into a future of …
The Staphylococcus aureus Network Adaptive Platform Trial Protocol: New Tools for an Old Foe
Staphylococcus aureus bloodstream (SAB) infection is a common and severe infectious
disease, with a 90-day mortality of 15%–30%. Despite this,< 3000 people have been …
disease, with a 90-day mortality of 15%–30%. Despite this,< 3000 people have been …
The end of the COVID‐19 pandemic
JPA Ioannidis - European journal of clinical investigation, 2022 - Wiley Online Library
There are no widely accepted, quantitative definitions for the end of a pandemic such as
COVID‐19. The end of the pandemic due to a new virus and the transition to endemicity may …
COVID‐19. The end of the pandemic due to a new virus and the transition to endemicity may …
[HTML][HTML] Saving millions of lives but some resources squandered: emerging lessons from health research system pandemic achievements and challenges
During the SARS-CoV-2 pandemic, astonishingly rapid research averted millions of deaths
worldwide through new vaccines and repurposed and new drugs. Evidence use informed …
worldwide through new vaccines and repurposed and new drugs. Evidence use informed …
[HTML][HTML] Establishing COVID-19 trials at scale and pace: experience from the RECOVERY trial
Abstract The Randomised Evaluation of COVID-19 Therapy (RECOVERY) Trial was set up
in March 2020 to evaluate treatments for people hospitalised with COVID-19. To maximise …
in March 2020 to evaluate treatments for people hospitalised with COVID-19. To maximise …
Benefits of streamlined point-of-care trial designs: lessons learned from the UK RECOVERY study
RM Califf, P Cavazzoni, J Woodcock - JAMA Internal Medicine, 2022 - jamanetwork.com
Recent findingsfrom the UK Randomised Evaluation of COVID-19 Therapy (RECOVERY)
trial group present an important learning opportunity for the clinical and clinical research …
trial group present an important learning opportunity for the clinical and clinical research …
Nipah virus disease: what can we do to improve patient care?
The year 2023 marked the 25th anniversary of the first detected outbreak of Nipah virus
disease. Despite Nipah virus being a priority pathogen in the WHO Research and …
disease. Despite Nipah virus being a priority pathogen in the WHO Research and …
Large scale clinical trials: lessons from the COVID-19 pandemic
AR Horsley, L Pearmain, S Knight… - BMJ open …, 2022 - bmjopenrespres.bmj.com
Background The COVID-19 pandemic has presented substantial new challenges to clinical
and research teams. Our objective was to analyse the experience of investigators and …
and research teams. Our objective was to analyse the experience of investigators and …
Accelerating clinical trials: time to turn words into action
MJ Landray, R Haynes, C Reith - The Lancet, 2023 - thelancet.com
As countries begin to navigate a post-pandemic world and health systems struggle to deal
with the burden of disease affecting the populations they serve, high-quality randomised …
with the burden of disease affecting the populations they serve, high-quality randomised …
[HTML][HTML] Sustaining a new model of acute stroke care: a mixed-method process evaluation of the Melbourne mobile stroke unit
Background: Internationally, Mobile Stroke Unit (MSU) ambulances have changed pre-
hospital acute stroke care delivery. MSU clinical and cost-effectiveness studies are …
hospital acute stroke care delivery. MSU clinical and cost-effectiveness studies are …