Abstract Application for Research Ethics Committee (REC) approval and the conduct of
medical research is paper intensive. This retrospective study examined all applications to a …

The FDA and other regulatory bodies have issued multiple guidance documents addressing
technology tools that are used in clinical trials. FDA guidance documents include …

Many research-funding agencies now require open access to the results of research they
have funded, and some also require that researchers make available the raw data …

Background Recent cohort studies of randomised controlled trials have provided evidence
of within-study selective reporting bias; where statistically significant outcomes are more …

Regulations and the number of forms that require completion remain a major frustration for
researchers attempting to establish a clinical research project. It is essential that clinical …

People who write and submit articles on behalf of the pharmaceutical, biotechnology, and
medical device industries should ensure accuracy and completeness and avoid any …

The reliability of publication affects evidence-based science. In recent years, science has
come under increasing scrutiny for its trustworthiness because of the misconduct of a few …

Objectives Approximately 40% of randomized controlled trials are not published. Advocates
of full reporting of clinical trials have argued nonpublication betrays trial participants and …

Viewpoint research ethics committees. He expressed his concern that if the journal reviewed
protocols, the increased workload would reduce the quality of the service it could provide for …

Background Publication and outcome reporting bias is often caused by researchers
selectively choosing which scientific results and outcomes to publish. This behaviour is …