Aims Opioids are commonly used on the intensive care unit (ICU) but are associated with a
high incidence of constipation, often resistant to conventional laxative treatment. Recently …

Purpose Constipation can be a significant problem in critically unwell patients, associated
with detrimental outcomes. Opioids are thought to contribute to the mechanism of bowel …

Background Opioid-induced constipation (OIC) has become more common in the intensive
care unit (ICU) due to increased opioid utilization. Traditional laxatives often prove …

Opioid antagonists in the ICU are often a last-line medication given to patients with opioid-
induced constipation. Traditionally, patients have been administered nonopioid-based …

PURPOSE: Opioid-induced constipation (OIC) is defined as fewer than 3 bowel movements
(BMs) per week according to the American Gastroenterology Association. It is a common …

Background: Constipation impacts 58% to 83% of critically ill patients and is associated with
increased time on mechanical ventilation, delirium, and increased length of stay (LOS) in the …

Methods: This was a retrospective, multi-center, cohort study of ICU patients admitted
between January 1, 2014 and September 1, 2022. Patients were included if received opioid …

Background. Constipation is frequent in critically ill adults receiving opioids. Naloxegol (N), a
peripherally acting mu-receptor antagonist (PAMORA), may reduce constipation. The …

Background: Opioid-induced constipation (OIC) may occur in up to 81% of critically ill
patients and can lead to many complications. Opioid antagonists are a reasonable approach …

Purpose To determine the safety and efficacy of enteral naloxone for the treatment of opioid-
induced constipation in the medical intensive care unit (MICU). Materials and Methods This …