Diabetes has historically been thought of as a medical specialty which primarily deals with
treatment rather than diagnosis. Molecular genetic testing can now be used to make a …

A molecular genetic diagnosis is now possible for> 80% of patients with monogenic
diabetes. This not only provides accurate information regarding inheritance and prognosis …

Most common diseases also run in families as rare, monogenic forms. Diabetes is no
exception. Mutations in approximately 20 different genes are now known to cause …

Monogenic diabetes results from one or more mutations in a single gene which might hence
be rare but has great impact leading to diabetes at a very young age. It has resulted in great …

Evidence for a genetic basis for type 2 diabetes and the metabolic syndrome has been
derived from studies of families, twins and populations with genetic admixture. Identification …

Defining the molecular genetics of diabetes gives new insight into the underlying etiology
and so should help improve treatment. The genetic etiology is now known for most patients …

Recently it has become apparent that not all diabetes presenting in childhood is type 1.
Increasingly type 2 diabetes, secondary diabetes, maturity onset diabetes of the young, and …

Diabetes mellitus and impaired fasting glucose associated with single gene mutations are
less rare than previously thought and may account for more than 6% of patients attending a …

Mutations in critical beta-cell genes can result in monogenic diabetes. This clinically
heterogeneous group of disorders usually presents soon after birth as neonatal diabetes, or …

Monogenic diabetes resulting from mutations that primarily reduce β-cell function accounts
for 1–2% of diabetes cases, although it is often misdiagnosed as either type 1 or type 2 …