Guy Thwaites regimens and, in many countries, are left untreated. 9 Other drugs exist, but to
date there have been no randomised controlled clinical trials to evaluate these regimens …

Targeted testing and treatment of individuals with latent tuberculosis infection at increased
risk of progression to active disease is a key element of tuberculosis control. This strategy is …

The century-old tuberculin skin test (TST) was until recently the only means of diagnosing
latent tuberculosis infection (LTBI). Recent advances in mycobacterial genomics and human …

A major challenge in tuberculosis control is the diagnosis and treatment of latent
tuberculosis infection. Until recently, there were no alternatives to the tuberculin skin test …

Molecular diagnostic tools have changed the approach to the detection of Mycobacterium
tuberculosis and associated drug-resistance substantially. PCR-based technologies allow a …

Elimination of tuberculosis in industrialized nations hinges on diagnosis and treatment of
latent tuberculosis infection to prevent disease. The tuberculin skin test is used to diagnose …

Until recently, skin testing with purified protein derivative of tuberculin was the only practical
way of detecting latent tuberculosis infection (LTBI). However, the tuberculin skin test (TST) …

In 1993, the World Health Organization declared tuberculosis (TB) a “global health
emergency”, drawing attention to a problem that had been largely ignored over the past few …

The first question is do we need any new anti-TB drugs since the majority of people who
currently die with TB actually have fully sensitive disease which has led some to advocate …

Background: Interferon-γ–release assays (IGRAs) are alternatives to the tuberculin skin test
(TST). A recent meta-analysis showed that IGRAs have high specificity, even among …