Aims Pain is the main symptom of osteoarthritis (OA) and can be detected in mice around 8
weeks following surgical destabilisation of the joint. In mice as well as patients, nerve growth …

Purpose: Pain is the main symptom of osteoarthritis (OA), with nearly ¾ of patients reporting
constant pain (ARUK report 2017). Within the last decade, nerve growth factor (NGF) has …

Objectives Nerve growth factor (NGF) has emerged as a key driver of pain in osteoarthritis
(OA) and antibodies to NGF are potent analgesics in human disease. Here, we validate a …

Biologic antibody therapeutics that target nerve growth factor (NGF) can alleviate
osteoarthritis (OA) pain, but would probably be expensive to use clinically. Furthermore …

Chronic pain resulting from inflammatory and neuropathic disorders causes considerable
economic and social burden. For a substantial proportion of patients, conventional drug …

Purpose: Pain is the foremost clinical symptom of osteoarthritis (OA), however the processes
that lead to pain in the joint are poorly understood. We have previously shown that nerve …

Purpose: Nerve growth factor (NGF) is under active investigation as a promising target for
treating osteoarthritis pain. Sensitization is a key process in many chronic pain states …

Systemic injection of a nerve growth factor (NGF) antibody has been proven to have a
significant relevance in relieving osteoarthritis (OA) pain, while its adverse effects remain a …

Background Nerve growth factor (NGF) is not only an important factor in nerve growth but
also a major contributor to the production of inflammation. It has been reported that inhibiting …

Arthritis is characterized by pain and inflammation. Recently, attention has been focused on
nerve-growth factor (NGF), a neurotrophin that is a key regulator of peripheral nociception …