The pathophysiological mechanisms of ACLF are incompletely understood. The natural
history of chronic liver disease involves the development of portal hypertension, ascites and …

There are different operating definitions for acute-on-chronic liver failure (ACLF) in different
geographic regions. Consortia in Western countries have developed definitions that apply to …

Acute-on-chronic liver failure (ACLF) is considered a distinct syndrome in patients with liver
disease, with systemic inflammation playing a central role. Portal hypertension (PHT) is also …

Acute-on-chronic liver failure (ACLF) is increasingly recognized as a complex syndrome that
is reversible in many cases. It is characterized by an acute deterioration of liver function in …

By elaborating on those mechanisms that are especially perturbed by inflammatory
responses, this article aims to show how this understanding has helped inform the …

Since the publication of the first article proposing the hypothesis that acute-on-chronic liver
failure (ACLF) was likely to be a distinct clinical condition, there are now over 400 fully …

Circulatory abnormalities are exaggerated in ACLF. The predominant mechanism is a
systemic inflammatory reaction. Modalities such as MARS improve serum markers of …

Acute on chronic liver failure (ACLF) is currently recognized as a specific entity
characterized by acute deterioration of liver function in the context of compensated or even …

BACKGROUND & AIMS: Patients with cirrhosis hospitalized for an acute decompensation
(AD) and organ failure are at risk for imminent death and considered to have acute-on …

Despite several advances in the understanding of liver disease, mortality of patients with
cirrhosis who develop complications of cirrhosis remains high. The concept of acute-on …