[HTML][HTML] Future mechanistic strategies for tackling fibrosis–an unmet need in liver disease

JA Fallowfield - Clinical medicine, 2015 - rcpjournals.org
Standardised mortality rates for liver disease in the UK have increased 400% since 1970.
However, evidence from a large number of animal models and clinical trials indicates that …

Therapeutic targets in liver fibrosis

JA Fallowfield - American Journal of Physiology …, 2011 - journals.physiology.org
Detailed analysis of the cellular and molecular mechanisms that mediate liver fibrosis has
provided a framework for therapeutic approaches to prevent, slow down, or even reverse …

Recent developments in targeting liver fibrosis

DM John Iredale - Clinical Medicine, 2008 - search.proquest.com
Liver fibrosis and cirrhosis present a continuous disease spectrum characterised by an
increase in total liver collagen and other matrix proteins which disrupt the architecture of the …

[HTML][HTML] Recent advances in understanding liver fibrosis: bridging basic science and individualized treatment concepts

R Weiskirchen, S Weiskirchen, F Tacke - F1000Research, 2018 - ncbi.nlm.nih.gov
Hepatic fibrosis is characterized by the formation and deposition of excess fibrous
connective tissue, leading to progressive architectural tissue remodeling. Irrespective of the …

Liver fibrosis: a bidirectional model of fibrogenesis and resolution

P Ramachandran, JP Iredale - QJM: An International Journal of …, 2012 - academic.oup.com
Liver fibrosis is the generic response to chronic injury of varying aetiologies. A number of
common mechanisms link this response to the pathogenesis of fibrosis in other organs …

Pathobiology of liver fibrosis: a translational success story

YA Lee, MC Wallace, SL Friedman - Gut, 2015 - gut.bmj.com
Reversibility of hepatic fibrosis and cirrhosis following antiviral therapy for hepatitis B or C
has advanced the prospect of developing antifibrotic therapies for patients with chronic liver …

Novel targeted therapies for the management of liver fibrosis

JP Trivella, P Martin, AF Carrion - Expert opinion on emerging …, 2020 - Taylor & Francis
Introduction: Prolonged liver injury results in tissue damage and replacement by
extracellular matrix and fibrosis. Cirrhosis represents a leading cause of mortality worldwide …

Preclinical promise and clinical challenges for innovative therapies targeting liver fibrogenesis

TA Addissouky, MMA Ali, IET El Sayed… - Archives of …, 2023 - scientificarchives.com
Liver fibrosis resulting from chronic liver injury can progress to cirrhosis and liver failure.
Current treatments are limited, creating an urgent need for novel antifibrotic therapies …

[HTML][HTML] Antifibrotic therapies: will we ever get there?

AJ Thompson, K Patel - Current gastroenterology reports, 2010 - Springer
Progressive hepatic fibrosis is the final common pathway for most chronic liver injuries,
leading to cirrhosis with risk of liver failure and hepatocellular carcinoma. It is now …

Evolving challenges in hepatic fibrosis

SL Friedman - Nature reviews Gastroenterology & hepatology, 2010 - nature.com
Continued elucidation of the mechanisms of hepatic fibrosis has yielded a comprehensive
and nuanced portrait of fibrosis progression and regression. The paradigm of hepatic …