Most cancer-related deaths are due to metastatic disease. There is now an emerging
evidence base suggesting that a subgroup of metastatic patients benefit significantly from …

Metastases remain the leading cause of cancer-related mortality. The oligometastasis
hypothesis postulates that a spectrum of metastatic spread exists and that some patients …

The definition of oligometastatic disease has evolved into distinct intermediate stages of
different prognosis between single metastasis and polymetastatic disease. We assessed the …

In this review, we outline the clinical and biologic evidence supporting the existence of an
oligometastatic state. We first discuss the surgical and radiotherapeutic data that …

It is clear from surgical series that there are selected patients presenting with localised
metastatic disease who can be cured by radical ablation of the metastasis. To date this has …

Patients with metastatic solid tumors are usually treated with palliative intent. Systemic
therapy and palliative radiation are often used, with the goals of prolonging survival or …

The oligometastatic paradigm implies that patients who develop a small number of
metastatic lesions might achieve long-term survival if all these lesions are ablated with …

The standard treatment choice for cancer metastasis has been systemic management,
including cytotoxic chemotherapy, hormonal manipulation, and targeted therapy. Emerging …

The use of local ablative therapy or metastasis-directed therapy is an emerging
management paradigm in oligometastatic and oligoprogressive cancer. Recent randomized …

PURPOSE The oligometastatic paradigm hypothesizes that patients with a limited number of
metastases may achieve long-term disease control, or even cure, if all sites of disease can …