Kidney transplants do not last for the natural lifespan of most recipients. Of the reasons why
transplants fail, damage by the immune system is the commonest cause. Understanding …

Donald E. Hricik, MD Kidney transplantation is the kidney replacement therapy of choice for
patients with kidney failure as long as there are no comorbid conditions that preclude the …

Although considerable progress has occurred in kidney transplantation, allograft loss
remains a substantial unresolved issue, leading to increased morbidity, mortality, and costs …

As of now, kidney transplantation is still the most effective remedy for end-stage renal
disease (1). However, transplant patients are still chronically challenged by graft rejection …

The traditionally understood pathological roles of B cells in organ transplant injury include
their differentiation to antibody secreting cells and their function as antigen presenting cells …

Despite advances in immunosuppression over the last three decades, long-term kidney
transplant survival is suboptimal, 1 and mechanisms of late graft injury are incompletely …

The burden of acute kidney injury (AKI) and chronic kidney disease (CKD) increases as
much as hardly any other malady apart from obesity in the United States and pulmonary …

Allotransplantation is the most common treatment for end stage kidney, liver, lung, and heart
disease. In order to accommodate the allograft, the recipient must be immune-suppressed …

B cells play a central role in the immunopathogenesis of glomerulonephritides and
transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple …

Solid organ transplant requires the removal of an organ from one individual, the donor, and
its placement in the recipient. Whether the donor is living or deceased, this process …