Science and serendipity

MB Pepys - Clinical Medicine, 2007 - ncbi.nlm.nih.gov
Good science demands independent replication of new ideas and results and abandonment
of accepted theories in light of more reliable evidence. Failure to comply leads to damaging …

C-reactive protein fifty years on

MB Pepys - The Lancet, 1981 - Elsevier
The discovery of C-reactive protein (CRP) half a century ago led to the description of the
acute-phase reaction which is a fundamental response of the body to injury. Recent work on …

[PDF][PDF] The crack in the biomedical box

Z Di Blasi - PSYCHOLOGIST-LEICESTER-, 2003 - academia.edu
CROCODILE dung, lozenges of dried vipers, blisters and bloodletting. Until this century most
medications were pharmacologically inert, if not harmful. Since the age of the scientific …

[BOOK][B] Advanced understanding of neurodegenerative diseases

RCC Chang - 2011 - books.google.com
Advanced Understanding of Neurodegenerative Diseases focuses on different types of
diseases, including Alzheimer's disease, frontotemporal dementia, different tauopathies …

Biomarkers for disease modification trials-The innovative medicines initiative and AddNeuroMed

S Lovestone, P Francis… - The journal of nutrition …, 2007 - search.proquest.com
In a previous issue of the Journal we reviewed the pressing and urgent need for biomarkers
in Alzheimer's Disease (AD)(1). This need has become no less urgent or pressing and …

[HTML][HTML] Stops making sense–For the people?

LS Valášek, J Lukeš, Z Paris - Clinical and Translational Medicine, 2023 - ncbi.nlm.nih.gov
Dear Editor, Thanks to the seminal work of Drs. Brenner, Jacob and Meselson from 1961, we
have come to realize that our life depends on 'an unstable intermediate (mRNA) carrying …

The aspirin story–from willow to wonder drug

MJR Desborough, DM Keeling - British journal of haematology, 2017 - Wiley Online Library
The story of the discovery of aspirin stretches back more than 3500 years to when bark from
the willow tree was used as a pain reliever and antipyretic. It involves an Oxfordshire …

The force of prions

L Manuelidis - The Lancet, 2000 - thelancet.com
Despite the impact of modern diagnostic techniques, the cause, the pathology, or the genetic
basis of many of the most common movement disorders are not known. An overview of …

[HTML][HTML] Public health and rare diseases: oxymoron no more

R Valdez, L Ouyang, J Bolen - Preventing chronic disease, 2016 - ncbi.nlm.nih.gov
The mission of public health has been succinctly stated as “the fulfillment of society's interest
in assuring conditions in which people can be healthy”(1). Public and private institutions …

A prion lexicon (out of control)

P Brown, L Cervenakova - The Lancet, 2005 - thelancet.com
In the beginning, there was the prion, a dyslexic acronym for pro teinaceous-in fectious
particle. In short order came PrP, an abbreviation for pr ion p rotein (or perhaps p roteinase-r …