[HTML][HTML] Glucocorticoids in bone and joint disease: the good, the bad and the uncertain
MS Cooper - Clinical medicine, 2012 - ncbi.nlm.nih.gov
Therapeutic glucocorticoids are widely used to treat a variety of inflammatory conditions.
However, the beneficial anti-inflammatory effects of glucocorticoids are limited by their …
However, the beneficial anti-inflammatory effects of glucocorticoids are limited by their …
Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss
Objectives Synovial fibroblasts and osteoblasts generate active glucocorticoids by means of
the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme. This activity increases …
the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme. This activity increases …
Targeting 11β-hydroxysteroid dehydrogenases: a novel approach to manipulating local glucocorticoid levels with implications for rheumatic disease
Systemic glucocorticoid excess causes osteoporosis, insulin resistance and central obesity.
Recently it has been recognized that tissue glucocorticoid levels can increase …
Recently it has been recognized that tissue glucocorticoid levels can increase …
[HTML][HTML] 11β-HSD1 plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy
Background Despite their efficacy in the treatment of chronic inflammation, the prolonged
application of therapeutic glucocorticoids (GCs) is limited by significant systemic side effects …
application of therapeutic glucocorticoids (GCs) is limited by significant systemic side effects …
Glucocorticoid metabolism in rheumatoid arthritis
Endogenous glucocorticoids are implicated in the development and resolution of
inflammation. Until recently it was thought that these glucocorticoids arose primarily from the …
inflammation. Until recently it was thought that these glucocorticoids arose primarily from the …
Glucocorticoids and bone: consequences of endogenous and exogenous excess and replacement therapy
Osteoporosis associated with long-term glucocorticoid therapy remains a common and
serious bone disease. Additionally, in recent years it has become clear that more subtle …
serious bone disease. Additionally, in recent years it has become clear that more subtle …
[HTML][HTML] Bad to the bone: the effects of therapeutic glucocorticoids on osteoblasts and osteocytes
M Gado, U Baschant, LC Hofbauer… - Frontiers in …, 2022 - frontiersin.org
Despite the continued development of specialized immunosuppressive therapies in the form
of monoclonal antibodies, glucocorticoids remain a mainstay in the treatment of …
of monoclonal antibodies, glucocorticoids remain a mainstay in the treatment of …
[HTML][HTML] 11β-Hydroxysteroid dehydrogenase type 1 within osteoclasts mediates the bone protective properties of therapeutic corticosteroids in chronic inflammation
CG Fenton, A Crastin, CS Martin, S Suresh… - International Journal of …, 2022 - mdpi.com
Therapeutic glucocorticoids (GCs) are powerful anti-inflammatory tools in the management
of chronic inflammatory diseases such as rheumatoid arthritis (RA). However, their actions …
of chronic inflammatory diseases such as rheumatoid arthritis (RA). However, their actions …
Bone effects of glucocorticoid therapy
KH Väänänen, PL Härkönen - Recent Advances in Glucocorticoid …, 2002 - Springer
Since the beginning of pharmacological use of glucocorticoids it has been clear that they
have serious adverse effects in bone. Chronic administration of glucocorticoids causes a …
have serious adverse effects in bone. Chronic administration of glucocorticoids causes a …
Corticosteroids in the treatment of rheumatologic diseases
EF Morand - Current opinion in rheumatology, 2000 - journals.lww.com
The year 2000 marks the fiftieth anniversary of the awarding of the Nobel Prize for Medicine
to Hench, Kendall, and Reichstein for their discovery of glucocorticoid treatment of rheumatic …
to Hench, Kendall, and Reichstein for their discovery of glucocorticoid treatment of rheumatic …