[HTML][HTML] Glucocorticoids in bone and joint disease: the good, the bad and the uncertain

MS Cooper - Clinical medicine, 2012 - ncbi.nlm.nih.gov
Therapeutic glucocorticoids are widely used to treat a variety of inflammatory conditions.
However, the beneficial anti-inflammatory effects of glucocorticoids are limited by their …

Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss

K Kaur, R Hardy, MM Ahasan, M Eijken… - Annals of the …, 2010 - ard.bmj.com
Objectives Synovial fibroblasts and osteoblasts generate active glucocorticoids by means of
the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme. This activity increases …

Targeting 11β-hydroxysteroid dehydrogenases: a novel approach to manipulating local glucocorticoid levels with implications for rheumatic disease

RS Hardy, MJ Seibel, MS Cooper - Current Opinion in Pharmacology, 2013 - Elsevier
Systemic glucocorticoid excess causes osteoporosis, insulin resistance and central obesity.
Recently it has been recognized that tissue glucocorticoid levels can increase …

[HTML][HTML] 11β-HSD1 plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy

CG Fenton, CL Doig, S Fareed, A Naylor… - Arthritis Research & …, 2019 - Springer
Background Despite their efficacy in the treatment of chronic inflammation, the prolonged
application of therapeutic glucocorticoids (GCs) is limited by significant systemic side effects …

Glucocorticoid metabolism in rheumatoid arthritis

RS Hardy, K Raza, MS Cooper - … of the New York Academy of …, 2014 - Wiley Online Library
Endogenous glucocorticoids are implicated in the development and resolution of
inflammation. Until recently it was thought that these glucocorticoids arose primarily from the …

Glucocorticoids and bone: consequences of endogenous and exogenous excess and replacement therapy

RS Hardy, H Zhou, MJ Seibel, MS Cooper - Endocrine reviews, 2018 - academic.oup.com
Osteoporosis associated with long-term glucocorticoid therapy remains a common and
serious bone disease. Additionally, in recent years it has become clear that more subtle …

[HTML][HTML] Bad to the bone: the effects of therapeutic glucocorticoids on osteoblasts and osteocytes

M Gado, U Baschant, LC Hofbauer… - Frontiers in …, 2022 - frontiersin.org
Despite the continued development of specialized immunosuppressive therapies in the form
of monoclonal antibodies, glucocorticoids remain a mainstay in the treatment of …

[HTML][HTML] 11β-Hydroxysteroid dehydrogenase type 1 within osteoclasts mediates the bone protective properties of therapeutic corticosteroids in chronic inflammation

CG Fenton, A Crastin, CS Martin, S Suresh… - International Journal of …, 2022 - mdpi.com
Therapeutic glucocorticoids (GCs) are powerful anti-inflammatory tools in the management
of chronic inflammatory diseases such as rheumatoid arthritis (RA). However, their actions …

Bone effects of glucocorticoid therapy

KH Väänänen, PL Härkönen - Recent Advances in Glucocorticoid …, 2002 - Springer
Since the beginning of pharmacological use of glucocorticoids it has been clear that they
have serious adverse effects in bone. Chronic administration of glucocorticoids causes a …

Corticosteroids in the treatment of rheumatologic diseases

EF Morand - Current opinion in rheumatology, 2000 - journals.lww.com
The year 2000 marks the fiftieth anniversary of the awarding of the Nobel Prize for Medicine
to Hench, Kendall, and Reichstein for their discovery of glucocorticoid treatment of rheumatic …