De testimonio: on the evidence for decisions about the use of therapeutic interventions
M Rawlins - The Lancet, 2008 - thelancet.com
William Harvey (1578–1657) was one of a group of 17th century natural philosophers who
were no longer prepared to accept the authority of Aristotle, Plato, and Galen as a reliable …
were no longer prepared to accept the authority of Aristotle, Plato, and Galen as a reliable …
Beyond randomised versus observational studies
J Concato, RI Horwitz - The Lancet, 2004 - thelancet.com
For personal use. Only reproduce with permission from The Lancet Publishing Group.
scientific quality, as well as the humanistic relevance, of patient-oriented research cannot be …
scientific quality, as well as the humanistic relevance, of patient-oriented research cannot be …
[HTML][HTML] Clinical trials should begin and end with systematic reviews of relevant evidence: 12 years and waiting
M Clarke, S Hopewell, I Chalmers - The lancet, 2010 - thelancet.com
If a new clinical trial is to be justifiable both scientifically and ethically it should be designed
in the light of an assessment of relevant previous research, ideally a systematic review. 1 …
in the light of an assessment of relevant previous research, ideally a systematic review. 1 …
Summing up evidence: one answer is not always enough
Are meta-analyses the brave new world, or are the critics of such combined analyses right to
say that the biases inherent in clinical trials make them uncombinable? Negative trials are …
say that the biases inherent in clinical trials make them uncombinable? Negative trials are …
Putting clinical trials into context
C Young, R Horton - The Lancet, 2005 - thelancet.com
May 20, 2005, saw the first ever international clinical trials day, 1 celebrating the contribution
of James Lind2 to the concept of medical research and recognising that biomedical research …
of James Lind2 to the concept of medical research and recognising that biomedical research …
Meta-analysis of the literature or of individual patient data: is there a difference?
LA Stewart, MKB Parmar - The Lancet, 1993 - Elsevier
The use of meta-analyses or overviews to combine formally the results of related
randomised clinical trials is becoming increasingly common. However the distinction …
randomised clinical trials is becoming increasingly common. However the distinction …
Evidence-based medicine and treatment choices
DL Sackett - The Lancet, 1997 - thelancet.com
SIR-contrary to the impression that might be gained from Maynard's essay (Jan 11, p
126),'we clinicians make cost-utility decisions all the time (eg, which of 20 admissions to see …
126),'we clinicians make cost-utility decisions all the time (eg, which of 20 admissions to see …
Evidence-based medicine: an incomplete method for informing treatment choices
A Maynard - The Lancet, 1997 - thelancet.com
Viewpoint patient and their relatives the choice of effective treatments. However, Sackett and
colleagues do not accept the social ethic associated with the pursuit of the maximum gains …
colleagues do not accept the social ethic associated with the pursuit of the maximum gains …
Can meta-analyses be trusted?
SG Thompson, SJ Pocock - The Lancet, 1991 - Elsevier
The enthusiasm for meta-analyses (or overviews) expressed by their proponents is not
always shared by the broader medical community. To encourage constructive debate, we …
always shared by the broader medical community. To encourage constructive debate, we …
The James Lind Alliance: patients and clinicians should jointly identify their priorities for clinical trials
N Partridge, J Scadding - The Lancet, 2004 - thelancet.com
Dec 1 sees the launch of the James Lind Alliance at the Clinical Excellence conference in
Birmingham, UK. Convened jointly by INVOLVE, the Royal Society of Medicine, and the …
Birmingham, UK. Convened jointly by INVOLVE, the Royal Society of Medicine, and the …