Method-related interference in thyroid function assays

N Wassef, J Sheffield, L Ward, W Wassif - Clinical Medicine, 2019 - ncbi.nlm.nih.gov
Aims To assess potential assay interference as the cause of aberrant thyroid-stimulating
hormone (TSH) and free thyroxine (FT4) results. Methods It is well documented that …

Interferences with thyroid function immunoassays: clinical implications and detection algorithm

J Favresse, MC Burlacu, D Maiter… - Endocrine reviews, 2018 - academic.oup.com
Automated immunoassays used to evaluate thyroid function are vulnerable to different types
of interference that can affect clinical decisions. This review provides a detailed overview of …

Heterophilic antibody interference with TSH measurement on different immunoassay platforms

X Cheng, X Guo, X Chai, Y Hu, X Lian, G Zhang - Clinica Chimica Acta, 2021 - Elsevier
Introduction Interference due to the presence of heterophilic antibodies may lead to falsely
low or high analyte concentrations, but falsely elevated values are more common in most …

[PDF][PDF] Interference in thyroid function immunoassays: clinical consequences

S Kuzmanovska, O Vaskova - Macedonian Pharmaceutical …, 2020 - repository.ukim.mk
Thyroid function tests are prone to analytical interference, which can cause misleading
results when performed on automated immunoassay analyzers. We present a case of a 68 …

Interference of anti-streptavidin antibodies: More common than we thought? In relation to six confirmed cases

V Ricci, MP Esteban, G Sand, MM Menises - Clinical Biochemistry, 2021 - Elsevier
Automated immunoassays are extensively used in routine laboratory diagnostics of
endocrine disorders because of their advantages, such as high sensitivity, precision, and …

Antibody Interference in Thyroid Assays: a case report

C Mura, S Menotti, L Zelano, R Novizio… - Endocrine …, 2021 - endocrine-abstracts.org
Background: Endogenous and exogenous factors may cause biochemical interferences with
thyroid function immunoassays. Interference can be caused by many mechanisms including …

[HTML][HTML] False biochemical diagnosis of hyperthyroidism in streptavidin-biotin-based immunoassays: the problem of biotin intake and related interferences

ML Piketty, M Polak, I Flechtner… - Clinical Chemistry and …, 2017 - degruyter.com
Immunoassays are now commonly used for hormone measurement, in high throughput
analytical platforms. Immunoassays are generally robust to interference. However …

Utility of dilution tests in investigating interference in the free thyroxine assay

M Oostendorp, EGWM Lentjes - Clinical Chemistry and Laboratory …, 2017 - degruyter.com
Interference, for instance due to the presence of heterophilic antibodies, is a well-known
pitfall in diagnostic immunoassays. Although these antibodies were reported to be present in …

Antibody interference in thyroid assays: a potential for clinical misinformation

N Despres, AM Grant - Clinical chemistry, 1998 - academic.oup.com
Measurements of thyrotropin and of total and free thyroxine and triiodothyronine are widely
used diagnostic methods for thyroid function evaluation. However, some serum samples will …

[HTML][HTML] Falsely diagnosed thyrotoxicosis caused by anti-streptavidin antibodies and pre-wash procedures

T Ishikawa, H Sakai, T Itaya, S Hirotsugu, J Shikuma… - Thyroid Research, 2021 - Springer
Background Anti-streptavidin antibodies are causal determinants of analytical interference
during Thyroid function tests, and numerous reports have detailed such interference, with …