2005; 5: 142–6 cortisone. A similar acquired phenotype is seen following the ingestion of
excessive quantities of liquorice or carbenoxolone; 14 here the active ingredient …

Two isoforms of 11β-hydroxysteroid dehydrogenase (11β-HSD) interconvert the active
glucocorticoid, cortisol, and inactive cortisone. 11β-HSD1 acts predominantly as an oxo …

The many similarities between the metabolic syndrome and Cushing's syndrome led to the
hypothesis that excess glucocorticoids (GC) are part of the pathogenesis linking their …

Cushing's syndrome invariably presents with a classical phenotype comprising central
adiposity, prominence of dorsal, supraclavicular and temporal fat pads, bruising, abdominal …

A characteristic feature of the ectopic ACTH syndrome is a state of mineralocorticoid excess,
although the etiology remains obscure. Some forms of endocrine hypertension, such as …

Excessive glucocorticoid receptor activation, as in Cushing's syndrome, results in central
obesity with insulin resistance, type 2 diabetes, dyslipidemia, and hypertension. The …

The metabolic syndrome X and Cushing's syndrome show similar symptoms but one major
difference: Plasma cortisol is not elevated in the metabolic syndrome. Evidence is …

11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2) plays a crucial role in converting
hormonally active cortisol to inactive cortisone, thereby conferring specificity on the …

Similarities between the metabolic syndrome and Cushing's syndrome, and reversibility of
the features of Cushing's syndrome, suggest that cortisol may contribute to the …

The metabolic syndrome consists of a constellation of co-associated metabolic
abnormalities such as insulin resistance, type 2 diabetes, dyslipidaemia, hypertension and …