drug preferentially to an inactive/toxic metabolite. 8 In an intriguing study, the latter group of
patients have been shown to respond favourably to a combination of thiopurine and …

The inflammatory bowel diseases (IBD) are complex immune-mediated inflammatory
diseases that are associated with significant morbidity around the world. As our …

What is known and objective The thiopurine medications are standard inflammatory bowel
disease treatments. Therapeutic failure is observed, however, often because of variable …

Aliment Pharmacol Ther 31, 640–647 Summary Background The thiopurine drugs,
azathioprine and mercaptopurine (MP), are established treatments for IBD. However …

Background and aims: Azathioprine and mercaptopurine remain first line
immunomodulatory treatments for inflammatory bowel disease. Toxicity and non-response …

Editorial: an argument for lowâ•’dose thiopurine allopurinol combination use as firstâ•’line
therapy in inflammatory b Page 1 potent and longer acting acid suppressants, namely …

The thiopurine immunomodulators azathioprine and 6-mercaptopurine are integral to the
management of inflammatory bowel disease (IBD), particularly as corticosteroid-sparing and …

Introduction In Inflammatory bowel disease (IBD) lack of response or side effects to
thiopurines (TP: azathioprine and mercaptopurine) are common (30–50%) and frequently …

Although the employment of thiopurine metabolites profiles to decide on allopurinol co-
therapy is intellectually appealing, their use in determining dosing decisions or use of …

Background: Immunomodulator therapy with the thiopurine analogues azathioprine or 6-
mercaptopurine is commonly prescribed for the treatment of inflammatory bowel disease …