Randomised controlled trials are the gold standard for testing the efficacy and safety of
health interventions, especially medications, and researchers in the UK are required to gain …

In 1987, just a year before his death, the British epidemiologist Archie Cochrane gave one of
his last public interviews. Cochrane had led an illustrious career, helping to establish the …

Randomised trials are the best method to determine the efficacy and safety of health
technologies. A recent report by Lord O'Shaughnessy highlighted many of the current …

Abstract The Medicines and Healthcare Products Regulatory Agency (MHRA) has
announced a new regulatory framework that aims to make it faster and easier to gain …

In the early days of randomised control trials the ability to reduce confounding from known
and unknown confounders rightly underpinned their rapid rise in methodological popularity …

Objective To evaluate the specific components of setting up a simple multicentre clinical
study four years after the new UK law on clinical trials was implemented in 2004. Design …

A randomised controlled trial sets out to do just one thing—to discover the truth. Pick up any
medical journal, and you can read about the need for a good randomised clinical trial to …

Medical research organisations are urging the European Union to review the regulation of
clinical trials because they say that excessive bureaucracy is hampering research into new …

Clinical trials must be conducted in ways that protect participants and produce reliable
results. Both are central tenets of the International Council for Harmonisation of Technical …

Background Recent developments aiming to standardise and streamline processes of
gaining the necessary approvals to carry out research in the National Health Service (NHS) …