Infectious disease has been a leading cause of death throughout human history. Indeed, at
the time of Thomas Linacre's practice in the sixteenth century, England was subject to a …

The study of the host genetic component of infectious disease is potentially one of the most
difficult areas of complex human genetic disease analysis for one major reason: the …

The observation that only a fraction of individuals infected by infectious agents develop
clinical disease raises fundamental questions about the actual pathogenesis of infectious …

Infectious pathogens have long been recognized as potentially powerful agents impacting
on the evolution of human genetic diversity. Analysis of large-scale case–control studies …

This book consists of 13 chapters that cover the spectrum of knowledge regarding host
genetic susceptibility to infection quite well. The chapters are written by authors with …

There is increasing evidence of genetic predisposition to both susceptibility and outcome in
human infection. Examples from animal studies, single‐gene immunological defects and …

Until the mid-nineteenth century, life expectancy at birth averaged 20 years worldwide,
owing mostly to childhood fevers. The germ theory of diseases then gradually overcame the …

Written by recognized authorities, this book summarizes significant advances in
understanding the complexity of host genetic susceptibility. Substantial progress has been …

Since the very beginning of medicine, physicians have realized that the clinical course of
infections varies greatly among individuals. They gradually recognized that both host and …