Suzanne Kite and Fiona Hicks wide inter-individual variability in morphine absorption and
metabolism may lead to a poor analgesic response in up to a third of patients. Other opioids …

Most cancer pain res ponds to pharrnacological measures, and successful treatment is
based on the administration of analgesies, according to the WHO analgesie ladder. For …

The 2008 World Cancer Declaration included a target to make effective pain control more
accessible. Several key documents highlight the importance of effective pain control …

Background Opioids are the oldest (Figure 20.1) and the most important analgesics in the
management of acute and cancer pain but their use is more controversial and challenging in …

The prevalence of cancer‐related pain is 64% among patients with metastatic, advanced, or
terminal cancer, 59% among patients undergoing anticancer treatment, and 33% among …

The past decade has seen much research on the mechanisms by which opioids promote
analgesia. The challenge for clinicians involved in the management of chronic cancer pain …

Opioids have a pivotal role in the management of moderate to severe Pain in cancer
patients. Appreciating their individual pharmacodynamics, as well as their pharmacokinetic …

During 2007, 11.7 million US men and women of all ages suffered from some form of
invasive cancer. During their illness, at least 70%(8.2 million) will experience pain …

Pain remains a highly prevalent problem for patients with cancer and typically falls into one
of 3 types: visceral, somatic, and neuropathic. A mechanistic, pathophysiologic approach to …

About 10%–15% of adults experience some chronic pain. 1 The prevalence is considerably
higher in certain populations like cancer, where pain affects more than twothirds with …