- © 2017 by the Association of Clinical Scientists, Inc.
Post-transplant Lymphoproliferative Disorder Presented in a Form of Primary Effusion Lymphoma with t (8; 14)
- Sadia Sultana⇑,
- Suhair Al Salihi,
- Nidhi Tandon,
- Jesse Jaso,
- Nghia D. Nguyen,
- Songlin Zhang and
- Jing Liu
- Department of Pathology and Laboratory Medicine, UTHealth McGovern Medical School, Houston, Texas, USA
- Address correspondence to Sadia Sultana, MD; Department of Pathology and Laboratory Medicine, UTHealth McGovern Medical School, 6431 Fannin Street, MSB. 2.202, Houston, Texas, USA; phone: 832 533 2177; e mail: sadia.sultana{at}uth.tmc.edu
Abstract
Post-transplant lymphoproliferative disorders (PTLD) are emergent complications of organ transplantation occurring in 2% to 10% of transplanted patients. Epstein–Barr virus (EBV) infections are considered the most important factors for the development of these heterogeneous disorders. Primary effusion lymphoma (PEL) is a lymphoproliferative disorder predominantly described in patients with advanced AIDS and it is almost universally associated with human herpesvirus 8 (HHV8). In rare case, PEL also occurs in HHV8-negative patient, in the setting of hepatitis B and C virus infection. However, all these cases showed pan B-cell markers to be positive. Here, we report a case of PTLD presented as HHV8-negative and HIV-negative primary effusion lymphoma lacking near all lymphoid markers except PAX5 on immunohistochemistry, which created a diagnostic challenge. The diagnosis requires multiple approaches including molecular and genetic tests.
