Article Figures & Data
Tables
Wells Score PE No PE High n=224 (37.9%) 72 (32.1%) 152 (67.9%) Intermediate n=262 (44.3%) 55 (21.0%) 207 (79.0%) Low n=76 (12.9%) 15 (19.7%) 61 (80.3%) Not documented n=29 (4.9%) 6 (20.7%) 23 (79.3%) PE No PE Significance level Number 69 260 Age 71 [64–82] 71 [63–79] p=0.40 Female 49.3% 54.6% p=0.51 D-dimer 1584 [976–3,773] 505 [320–912] p<0.001 PE = pulmonary embolism
- Table 3.
Distribution of D-dimer results for conventional and age-adjusted cut-offs and patient's age per decade
Conventional D-dimer Age-adjusted D-dimer Age group Number TP FP FN TN TP FP FN TN All ages 329 69 242 0 18 67 176 2 84 50–59 59 11 38 0 10 11 32 0 16 60–69 90 18 68 0 4 18 52 0 20 70–79 96 18 75 0 3 17 48 1 30 80–89 68 17 50 0 1 16 37 1 14 90–99 16 5 11 0 0 5 7 0 4 FN = false negative; FP = false positive; TN = true negative; TP = true positive
- Table 4.
Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of conventional and age adjusted D-dimer (value and 95% confidence interval)
Conventional D-dimer Age-adjusted D-dimer Age group Number Sensitivity Specificity PPV NPV Sensitivity Specificity PPV NPV All ages 329 1.00 (0.95–1.00) 0.07 (0.04–0.11) 0.22 (0.18–0.27) 1.00 (0.81–1.00) 0.97 (0.90–1.00) 0.32 (0.27–0.38) 0.28 (0.22–0.34) 0.98 (0.92–1.00) 50–59 59 1.00 (0.72–1.00) 0.21 (0.10–0.35) 0.22 (0.12–0.37) 1.00 (0.69–1.00) 1.00 (0.72–1.00) 0.33 (0.20–0.48) 0.26 (0.14–0.41) 1.00 (0.79–1.00) 60–69 90 1.00 (0.81–1.00) 0.06 (0.02–0.14) 0.21 (0.13–0.31) 1.00 (0.40–1.00) 1.00 (0.81–1.00) 0.28 (0.18–0.40) 0.26 (0.16–0.38) 1.00 (0.83–1.00) 70–79 96 1.00 (0.81–1.00) 0.04 (0.01–0.11) 0.19 (0.12–0.29) 1.00 (0.29–1.00) 0.94 (0.73–1.00) 0.38 (0.28–0.50) 0.26 (0.16–0.39) 0.97 (0.83–1.00) 80–89 68 1.00 (0.80–1.00) 0.02 (0.00–0.10) 0.25 (0.16–0.37) 1.00 (0.02–1.00) 0.94 (0.71–1.00) 0.27 (0.16–0.42) 0.30 (0.18–0.44) 0.93 (0.68–1.00) 90–99 16 1.00 (0.48–1.00) 0.00 (0.00–0.28) 0.31 (0.11–0.59) n/a (0.00–1.00) 1.00 (0.48–1.00) 0.36 (0.11–0.69) 0.42 (0.15–0.72) 1.00 (0.40–1.00)
Additional Files
Supplementary material
Files in this Data Supplement:
- S1 Suggested pathway to investigate for suspected pulmonary embolism.
- S2 Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 3 x age to 10 x age cut-offs.
- S3 Mean D-dimer and inverted age adjusted D-dimer - sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of our cohort using the Lapner et al criteria.
