Skip to main content

Main menu

  • Home
  • Our journals
    • Clinical Medicine
    • Future Healthcare Journal
  • Subject collections
  • About the RCP
  • Contact us

Clinical Medicine Journal

  • ClinMed Home
  • Content
    • Current
    • Ahead of print
    • Archive
  • Author guidance
    • Instructions for authors
    • Submit online
  • About ClinMed
    • Scope
    • Editorial board
    • Policies
    • Information for reviewers
    • Advertising

User menu

  • Log in

Search

  • Advanced search
RCP Journals
Home
  • Log in
  • Home
  • Our journals
    • Clinical Medicine
    • Future Healthcare Journal
  • Subject collections
  • About the RCP
  • Contact us
Advanced

Clinical Medicine Journal

clinmedicine Logo
  • ClinMed Home
  • Content
    • Current
    • Ahead of print
    • Archive
  • Author guidance
    • Instructions for authors
    • Submit online
  • About ClinMed
    • Scope
    • Editorial board
    • Policies
    • Information for reviewers
    • Advertising

Self-assessment questions: The hepato-enteric immune axis in health and disease

Palak J Trivedi and David H Adams
Download PDF
DOI: https://doi.org/10.7861/clinmedicine.12-6-s79
Clin Med December 2012
Palak J Trivedi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David H Adams
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading
  1. The liver is able to generate a vigorous immune response to pathogenic organisms entering through the portal circulation while simultaneously being tolerogenic to harmless food-borne antigens. Which of the following statements regarding the hepatic immune response are true?

    1. A vigorous intrahepatic immune response depends on activation of T-cells by hepatic-resident antigen- presenting cells

    2. A vigorous intrahepatic immune response depends on activation of DCs by liver-resident T-cells

    3. Direct activation of T-cells within the liver by hepatic- resident antigen-presenting cells usually results in tolerance

    4. Direct activation of DCs within the liver by hepatic-resident T-cells usually results in tolerance

    5. IL10 promotes the development of effector T-cells over Tregs

  2. Primary sclerosing cholangitis (PSC) is strongly associated with inflammatory bowel disease (IBD). Which of the following questions regarding PSC and IBD are correct?

    1. The majority of patients with IBD have PSC

    2. Patients with PSC and IBD are have a lower lifetime risk of developing colonic carcinoma than patients with IBD alone

    3. Colectomy for ulcerative colitis prevents the development of PSC

    4. Patients with PSC and IBD have a greater lifetime risk of developing colonic carcinoma than patients with IBD alone

    5. Crohn's disease is more common than ulcerative colitis in patients with PSC

  3. Regarding enterohepatic lymphocyte homing, which of the following statements are false?

    1. CCL25 and α4β7 are constitutively expressed on the sinusoidal endothelium in normal human liver

    2. CCL25 and MAdCAM-1 are upregulated in the human liver in PSC

    3. Mucosal VAP-1 expression is upregulated in ulcerative colitis

    4. MAdCAM-1 is constitutively expressed on the lamina propria of the small bowel

    5. VAP-1 is constitutively expressed on the human liver sinusoidal endothelium

  4. Which of the following statements is correct?

    1. Enzymatic action of MAdCAM-1 leads to the upregulation of VAP-1 expression

    2. Neutralising antibodies against MAdCAM-1 are efficacious in treating PSC

    3. MAdCAM-1 possesses amine oxidase activity and also functions as an adhesion molecule

    4. Patients who develop PSC after being diagnosed with IBD have a better outcome than those who are diagnosed with PSC before being diagnosed with IBD

    5. Colectomy for ulcerative colitis before liver transplant is more protective against PSC recurrence in the liver allograft than colectomy performed 10 years after transplant

Answers to these self-assessment questions can be found on page s92.

  • © 2012 Royal College of Physicians
Back to top
Previous articleNext article

Article Tools

Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Self-assessment questions: The hepato-enteric immune axis in health and disease
Palak J Trivedi, David H Adams
Clinical Medicine Dec 2012, 12 (Suppl 6) s79; DOI: 10.7861/clinmedicine.12-6-s79

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Self-assessment questions: The hepato-enteric immune axis in health and disease
Palak J Trivedi, David H Adams
Clinical Medicine Dec 2012, 12 (Suppl 6) s79; DOI: 10.7861/clinmedicine.12-6-s79
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

Similar Articles

Navigate this Journal

  • Journal Home
  • Current Issue
  • Ahead of Print
  • Archive

Related Links

  • ClinMed - Home
  • FHJ - Home
clinmedicine Footer Logo
  • Home
  • Journals
  • Contact us
  • Advertise
HighWire Press, Inc.

Follow Us:

  • Follow HighWire Origins on Twitter
  • Visit HighWire Origins on Facebook

Copyright © 2021 by the Royal College of Physicians