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Perspective: Vitamin D supplementation prevents rickets and acute respiratory infections when given as daily maintenance but not as intermittent bolus: implications for COVID-19

George Griffin, Martin Hewison, Julian Hopkin, Rose Anne Kenny, Richard Quinton, Jonathan Rhodes, Sreedhar Subramanian and David Thickett
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DOI: https://doi.org/10.7861/clinmed.2021-0035
Clin Med March 2021
George Griffin
ASt George's, University of London, London, UK
Roles: emeritus professor of infectious diseases and medicine
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Martin Hewison
BUniversity of Birmingham, Birmingham, UK
Roles: professor of molecular endocrinology
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Julian Hopkin
CSwansea University, Swansea, UK
Roles: rector of medicine and health and professor of experimental medicine
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Rose Anne Kenny
DTrinity College Dublin, Dublin, Ireland
Roles: professor of medical gerontology
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Richard Quinton
ENewcastle University, Newcastle upon Tyne, UK
Roles: senior lecturer in endocrinology
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Jonathan Rhodes
FUniversity of Liverpool, Liverpool, UK
Roles: emeritus professor of medicine
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  • For correspondence: rhodesjm@liverpool.ac.uk
Sreedhar Subramanian
GRoyal Liverpool University Hospital, Liverpool, UK
Roles: consultant gastroenterologist
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David Thickett
HUniversity of Birmingham, Birmingham, UK
Roles: professor in respiratory medicine
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Article Information

vol. 21 no. 2 e144-e149
DOI: 
https://doi.org/10.7861/clinmed.2021-0035
PubMed: 
33593830
Published By: 
Royal College of Physicians
Print ISSN: 
1470-2118
Online ISSN: 
1473-4893
History: 
  • Published online March 24, 2021.

Article Versions

  • Latest version (February 16, 2021 - 07:18).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© Royal College of Physicians 2021. All rights reserved.

Author Information

  1. George Griffin, emeritus professor of infectious diseases and medicineA,
  2. Martin Hewison, professor of molecular endocrinologyB,
  3. Julian Hopkin, rector of medicine and health and professor of experimental medicineC,
  4. Rose Anne Kenny, professor of medical gerontologyD,
  5. Richard Quinton, senior lecturer in endocrinologyE,
  6. Jonathan Rhodes, emeritus professor of medicineF⇑,
  7. Sreedhar Subramanian, consultant gastroenterologistG and
  8. David Thickett, professor in respiratory medicineH
  1. ASt George's, University of London, London, UK
  2. BUniversity of Birmingham, Birmingham, UK
  3. CSwansea University, Swansea, UK
  4. DTrinity College Dublin, Dublin, Ireland
  5. ENewcastle University, Newcastle upon Tyne, UK
  6. FUniversity of Liverpool, Liverpool, UK
  7. GRoyal Liverpool University Hospital, Liverpool, UK
  8. HUniversity of Birmingham, Birmingham, UK
  1. Address for correspondence: Prof Jonathan Rhodes, Department of Cellular and Molecular Physiology, Institute of Translational Medicine, Henry Wellcome Laboratory, Nuffield Building, Crown Street, Liverpool L69 3GE, UK. Email: rhodesjm{at}liverpool.ac.uk

Article usage

Article usage: February 2021 to May 2022

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Mar 202148270300
Apr 20212220143
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Jun 2021021882
Jul 2021113569
Aug 202119452
Sep 2021110586
Oct 2021112581
Nov 2021068105
Dec 20210104124
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Perspective: Vitamin D supplementation prevents rickets and acute respiratory infections when given as daily maintenance but not as intermittent bolus: implications for COVID-19
George Griffin, Martin Hewison, Julian Hopkin, Rose Anne Kenny, Richard Quinton, Jonathan Rhodes, Sreedhar Subramanian, David Thickett
Clinical Medicine Mar 2021, 21 (2) e144-e149; DOI: 10.7861/clinmed.2021-0035

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Perspective: Vitamin D supplementation prevents rickets and acute respiratory infections when given as daily maintenance but not as intermittent bolus: implications for COVID-19
George Griffin, Martin Hewison, Julian Hopkin, Rose Anne Kenny, Richard Quinton, Jonathan Rhodes, Sreedhar Subramanian, David Thickett
Clinical Medicine Mar 2021, 21 (2) e144-e149; DOI: 10.7861/clinmed.2021-0035
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  • Article
    • ABSTRACT
    • Introduction: contradictory results of vitamin D supplementation in clinical trials
    • Evidence that low-dose daily vitamin D supplementation is effective but intermittent high-dose bolus is not
    • A plausible biological mechanism underlies the lack of efficacy of intermittent high-dose (bolus) vitamin D
    • Implications for COVID-19
    • Conflicts of interest
    • References
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