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- Published online March 24, 2021.
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- Latest version (February 16, 2021 - 07:18).
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© Royal College of Physicians 2021. All rights reserved.
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- George Griffin, emeritus professor of infectious diseases and medicineA,
- Martin Hewison, professor of molecular endocrinologyB,
- Julian Hopkin, rector of medicine and health and professor of experimental medicineC,
- Rose Anne Kenny, professor of medical gerontologyD,
- Richard Quinton, senior lecturer in endocrinologyE,
- Jonathan Rhodes, emeritus professor of medicineF⇑,
- Sreedhar Subramanian, consultant gastroenterologistG and
- David Thickett, professor in respiratory medicineH
- ASt George's, University of London, London, UK
- BUniversity of Birmingham, Birmingham, UK
- CSwansea University, Swansea, UK
- DTrinity College Dublin, Dublin, Ireland
- ENewcastle University, Newcastle upon Tyne, UK
- FUniversity of Liverpool, Liverpool, UK
- GRoyal Liverpool University Hospital, Liverpool, UK
- HUniversity of Birmingham, Birmingham, UK
- Address for correspondence: Prof Jonathan Rhodes, Department of Cellular and Molecular Physiology, Institute of Translational Medicine, Henry Wellcome Laboratory, Nuffield Building, Crown Street, Liverpool L69 3GE, UK. Email: rhodesjm{at}liverpool.ac.uk
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Perspective: Vitamin D supplementation prevents rickets and acute respiratory infections when given as daily maintenance but not as intermittent bolus: implications for COVID-19
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- ABSTRACT
- Introduction: contradictory results of vitamin D supplementation in clinical trials
- Evidence that low-dose daily vitamin D supplementation is effective but intermittent high-dose bolus is not
- A plausible biological mechanism underlies the lack of efficacy of intermittent high-dose (bolus) vitamin D
- Implications for COVID-19
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